NMN stands for nicotinamide mononucleotide, a molecule naturally occurring in all life forms. At the molecular level, it is a ribo-nucleotide, which is a basic structural unit of the nucleic acid RNA. Structurally, the molecule is composed of a nicotinamide group, a ribose and a phosphate group. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells.
Research indicates that NMN is the best way to boost levels of NAD+which is a key molecule in producing energy. As we age our body produces lower amounts of NAD+. This is turn affects a lot of systems in the body.
A 2019 mice study showed that cerebral blood flow, which has an essential role in maintenance of healthy brain function, was improved by NMN. Blood flow is essential for a washout of harmful metabolites and to deliver oxygen and nutrients to the energy-hungry brain, given that the brain itself has limited energy reserves.
The study noted that NMN activated sirtuin genes and increased biogenesis of mitochondria (the body's enegy producers). Both of these help to reduce the cognitive decline of old age.
By restoring NAD+ levels we can reduce, delay, or even reverse age-related diseases.
The main benefits appear to be in chronis conditions such as diabetes, cognitive impairment, and cardiovascular conditions.
a Japanese study published in 2022 looked at 108 older adults and assessed their sleep when taking NMN. Significant improvements were found in both the quality and duration of sleep.
When taken in the afternoon it significantly reduced fatigue and improved lower limb function.
NMN activates DNA repair mechanisms (sirtuins) in cells. This means that cells behave like they should do when you are young.
This is important because a gradual decline in DNA quality leads to cells becoming inert zombie cells with reduced function. When cells stop working properly problems occur: skin becomes wrinkled, brain connections are lost and liver and kidney cell lose function.
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